Heng, Ming Yuan and Thuerig, Barbara and Danton, Ombeline and Ramseyer, Justine and Gupta, Mahabir P. and Tamm, Lucius and Hamburger, Matthias and Potterat, Olivier (2022) Ingadosides A-C, acacic acid-type saponins from Inga sapindoides with potent inhibitory activity against downy mildew. Phytochemistry, 199. pp. 1-8.
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Abstract
As part of a project aiming at the discovery of environmentally friendly alternatives to copper in organic agriculture, a 96% ethanolic extract from the leaves of Inga sapindoides showed potent inhibitory activity against grapevine downy mildew (Plasmopara viticola) in vitro (MIC100 25 μg/mL). Separation of the n-BuOH soluble fraction by silica gel column chromatography followed by a combination of RP18 and HILIC HPLC resulted in the isolation of a series of bidesmosidic saponins characterized by the presence of a monoterpenoid unit attached to a triterpenoid aglycone, a p-methoxycinnamoyl residue, and rare sugar residues such as N-acetyl-D-glucosamine, Dquinovose, and D-fucose. The isolated compounds inhibited the formation or activity of P. viticola zoospores with MIC100 values of 3 or 6 μg/mL, respectively. I. sapindoides, a tree which is often cultivated for shading coffee plantations in Central America, may represent a sustainable source of fungicidal products to be used in the replacement of copper.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Inga sapindoides, fabaceae, plasmopara viticola, antifungal activity, saponins, ingadosides A-C |
| Subjects: | Q Science > Q Science (General) Q Science > QK Botany |
| Depositing User: | Fergie Pineda |
| Date Deposited: | 01 Nov 2023 14:37 |
| Last Modified: | 01 Nov 2023 14:37 |
| URI: | http://up-rid.up.ac.pa/id/eprint/6905 |
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