Bioactivity profiling of plant biodiversity of Panama by high throughput screening

Roy, Anuradha and McDonald, Peter and Timmermann, Barbara N. and Gupta, Mahabir and Chaguturu, Rathnam (2019) Bioactivity profiling of plant biodiversity of Panama by high throughput screening. Natural Product Communications, 14 (1). pp. 71-74.

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We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential, anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and neurodegenerative disorders.

Item Type: Article
Uncontrolled Keywords: Bioprospection, plants, Panama, biomedicine, screening, cancer, alzheimer, anti-inflammation, total antioxidant capacity, antioxidant response element, cytotoxicity, IL-2.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User: Fergie Pineda
Date Deposited: 02 Nov 2023 01:07
Last Modified: 02 Nov 2023 01:07

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